Kaley Cuoco doesn’t see herself filming another series like The Big Bang Theory in her career.
“That Big Bang time, I guess that was more like … a really once in a [lifetime experience],” Cuoco, 40, said during the Monday, February 9, episode of Dax Shepard’s “Armchair Expert” podcast. “I can’t even think to be like, ‘Oh I wish I had that again.’ That never crosses my mind.”
Cuoco explained that working on The Big Bang Theory , was a “special” experience, which can’t be recreated.
“That was its own life. I will never go back to that,” she told Shepard. “I talk about it with so much love but life is different now. It just doesn’t look that way. It will never look that way again.”
Cuoco starred on The Big Bang Theory from 2007 to 2019 alongside Johnny Galecki, Jim Parsons, Simon Helberg and Kunal Nayyar. The comedy ran for 12 seasons and followed two scientists and friends played by Parsons and Galecki who meet Cuoco’s character, Penny, when she moves into the apartment across from theirs.
On the show, Cuoco and Galecki played love interests and off screen, they dated for several years. They split in 2009. (Cuoco is currently engaged to Tom Pelphrey while Johnny is married to wife Morgan Galecki.)
Despite their breakup, Cuoco and Johnny remain close friends. During a recent appearance on Andy Cohen’s Watch What Happens Live, the actress revealed that while there’s not an active Big Bang Theory group chat, she and Johnny are still in touch.
“There’s one with me and Johnny. All the time,” said Cuoco earlier this month.
While Cuoco believes that the magic that was behind The Big Bang Theory couldn’t happen today, the show’s spirit does live on through its multiple spinoffs. While Big Bang Theory was still airing, the prequel series, Young Sheldon, premiered in 2017. The comedy told Sheldon’s backstory as a boy genius growing up in Texas. The show starred Iain Armitage, Zoe Perry, Lance Barber, Montana Jordan, Raegan Revord, Annie Potts and Matt Hobby.
In addition to learning about Sheldon’s backstory, Big Bang Theory fans got a deeper look into his family dynamic. Jordan, who played Sheldon’s brother Georgie, was a breakout star. When Young Sheldon came to an end in 2024 after seven seasons, it was announced that Jordan would be starring in his own spinoff series, Georgie and Mandy’s First Marriage, alongside Emily Osment. Georgie and Mandy’s First Marriage premiered in 2024 and is currently in its second season.
Last year, it was announced that a new series focusing on the Big Bang Theory character Stuart (Kevin Sussman) was in the works. Big Bang Theory alums Brian Posehn and Lauren Lapkus will star in the show along with Sussman as they reprise their characters.
Stuart Fails to Save the Universe follows comic book store owner Stuart Bloom who “is tasked with restoring reality after he breaks a device built by Sheldon and Leonard, accidentally bringing about a multiverse Armageddon,” according to the series official synopsis.










