Chelsea Handler’s Celebrity BFFs

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Jennifer Aniston

The two stars have vacationed in Cabo San Lucas, Mexico and Aspen, Colorado together. Handler even hosted Thanksgiving at her home for Aniston and beau Justin Theroux in November 2011.

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Leah Remini

The two pals joined forces for an online web series called In the Motherhood in 2007. "Leah had called and asked me if I wanted to play a mother with her, and I said, 'Of course,'" Handler explains. "It was really fun."

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Reese Witherspoon

"The great thing about Chelsea is she appeals to so many women by just being herself," gushes Witherspoon, Handler's costar in This Means War. "She is honest, engaging, and genuinely curious about other people's lives."

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Jay Leno

Handler often appears on The Tonight Show With Jay Leno, where she often teases him about his "lame" jokes. "You are so f-cking stupid," she told her pal.

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Charlize Theron

The two become pals after Theron appeared on Chelsea Lately in December 2011. Handler invited the Young Adult star to her Super Bowl party in February 2012, and Theron arrived with a big box of Dogfish Head Ale and two bottles of Belvedere Vodka.

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Katie Couric

"She can knock 'em back. She's pretty immature for a news woman," Handler has said of her journalist pal. "I think she likes hanging out with me because people don't believe that we're friends."

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Chuy Bravo

Handler hired the 4-foot-3 "nugget" to be her sidekick on Chelsea Lately, and they've been like family ever since. Handler has "made all my dreams come true," explains Bravo, who once called the E! host his "angel."

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Robin Wright

Handler frequently texts the Forrest Gump actress screen shots from her movies. "The problem is you send me the same pictures every month," Wright joked on Chelsea Lately. The two spent Thanksgiving 2011 together with Jennifer Aniston and Justin Theroux.

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Ross Mathews

When Handler goes on vacation, she often asks the bubbly comic to fill in for her as host of Chelsea Lately.

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Piers Morgan

The two frequently appear on each other's eponymous talk shows. "You have some similarities with Larry King," Handler once teased Morgan. "You do like to interrupt a lot."

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Heather McDonald

"She set up a scholarship fund for each of my kids and does the same for anyone on staff who has a baby," McDonald, a writer on Chelsea Lately, tells Redbook. "Yet she never went to college herself. She's a really sensitive person."