Brangelina’s Surprising BFFs!

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Bono

A big time humanitarian like the Jolie-Pitts, the U2 frontman, 50, also serves as godfather to two-year-old twins, Knox and Vivienne.

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Chris Cornell

Pitt and daughter Zahara, 5, helped rocker pal Cornell celebrate his daughter Toni's 6th birthday at the American Girl store in L.A. in September.

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Clint Eastwood

Jolie and Eastwood, 80, became buddies on the set of 2008's Changeling, in which he directed the actress. Eastwood dubbed their friendship "Clintalina."

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George Clooney

Clooney recently praised friend and sometimes co-star Pitt on his charitable work in New Orleans. "He's hit us all up on building houses there. I haven't seen anybody work as hard as he's done on that," Clooney told Access Hollywood at the 2010 Emmys.

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Gwen Stefani

When Jolie, 35, and Pitt, 46, head out on double dates with Stefani, 40, and Gavin Rossdale, 42, they leave their kids (the Jolie-Pitts have six, Stefani and Rossdale have two) behind to play together.

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Ted Gibson

"Working with Angelina Jolie changed my life professionally and spiritually," the celebrity hairstylist tells Vanity Fair.

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Mariane Pearl

The two women became friends (complete with play dates for the kids) after Jolie read an interview about the widow of slain journalist Daniel Pearl. Jolie then played Mariane in 2007's A Mighty Heart.

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Matt Damon

Damon and Pitt collaborated on the Ocean's Eleven movies. Next up, the two pals will join forces again by lending their voices to Happy Feet 2, out in 2011.

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Wyclef Jean

Jean is not shy about sharing parenting advice with the couple. In the past he's encouraged them to adopt a child from Haiti and even to use Carol's Daughter hair products on Zahara's hair.