Stars With Twins!

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PATRICK DEMPSEY AND TWINS DARBY AND SULLIVAN

He's McDreamy to the masses, but Dempsey's most important role? Dad to 6-year-old Tallula and twin 13-month-old sons Darby and Sullivan. Married to makeup artist Jill Fink, 40, the proud papa, 42, told Us, in October 2006, "I'm trying to have a calm family life, to make my marriage work."

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SEAN COMBS AND TWINS D'LILA AND JESSIE

"They're trying to stand up and discover everything," father Sean "Diddy" Combs tells Us of his twin daughters, 14 months (mom is ex Kim Porter). "All it takes is one look from them and my heart melts."

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MELISSA ETHERIDGE AND TWINS MILLER AND JOHNNIE

"The creation of life brings about immeasurable love, and pours hope into the future. The joy will help carry us through our upcoming sleepless nights," said singer Melissa Etheridge, 46, of raising twins - Miller Steven and Johnnie Rose, now age 1 1/2 - with partner Tammy, who carried the babies.

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MARCIA GAY HARDEN AND TWINS HUDSON AND JULITTA

The working mom, 48, spent quality time with her 3-year-old twins Hudson and Julitta (she also has daughter Eulala, age 9) on the set of Law and Order in January of 2006, but says it isn't always easy being a showbiz mom. "It's hard to balance work and family."

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NANCY GRACE AND TWINS JOHN AND LUCY

The CNN Headline News anchor welcomed twins, John and Lucy, with husband David Lynch, on November 4. For Grace, having twins has been a life-changing experience. She says, "When you love something so much, even tiny little things that weigh less than ten pounds each, everything is a wonder!"

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HOLLY HUNTER AND TWINS

Actress Holly Hunter, 49, is just like Us! In January, she went food shopping at Deli Market on University Place in New York City, and then took a leisurely walk home with actor beau Gordon MacDonald and twin sons, now age 2.

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BRAD PITT AND ANGELINA JOLIE

Twins Knox and Vivienne were born July 12 in Nice, France. "[Angelina] was awake and speaking and laughing," the actress' doctor said. "They were happy."

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JENNIFER LOPEZ AND MARC ANTHONY

Max and Emme were born on February 22 in New York's Long Island. The twins are "fantastic!" Lopez tells Us.

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MARCIA CROSS AND TWINS EDEN AND SAVANNAH

The Desperate Housewives star, 45, always wanted children, but she never expected to have two at once!  Cross remembers the panic that overcame her when she heard the big news: "I was sort of blown away that I was having twins, so I just needed a minute to deal with it."

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DENNIS QUAID AND TWINS THOMAS AND ZOE

Dennis Quaid, 53, and wife Kimberly Buffington didn't get to welcome their now 3-month-old twins Thomas and Zoe into the world the way they had imagined - the twins were given an accidental drug overdose at L.A.'s Cedar-Sinai Medical Center when they were just 12 days old.

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JULIA ROBERTS AND TWINS PHINNAEUS AND HAZEL

Julia Roberts, 40, tells Us, "[My kids are] fun and happy and honest and just fill me with so much joy. I guess I didn't realize that you could really just like your children as much as your friends, you know?"

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REBECCA ROMIJN AND JERRY O'CONNELL

A rep for the couple, married since 2007, confirmed to Us exclusively they're expecting twins this winter!